Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study.

Abstract

BACKGROUND:

Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 is associated with worse prognosis in previous lung diseases patients. But the prognosis of aPAP patients after infection with COVID-19 is unclear. In December 2022, China experienced a large-scale outbreak of Omicron variant of the SARS-CoV-2. In this study, we aim to explore the clinical outcomes of aPAP patients infected with COVID-19.

RESULTS:

A total of 39 aPAP patients were included in this study. 30.77% patients had a decrease in oxygen saturation after COVID-19 infection. We compared the two groups of patients with or without decreased oxygen saturation after COVID-19 infection and found that patients who had previous oxygen therapy (decreased oxygen saturation vs. non decreased oxygen saturation: 6/12 vs. 4/27, P = 0.043), with lower baseline arterial oxygen partial pressure (74.50 ± 13.61 mmHg vs. 86.49 ± 11.92 mmHg, P = 0.009), lower baseline DLCO/VA% [77.0 (74.3, 93.6) % vs. 89.5 (78.2, 97.4) %, P = 0.036], shorter baseline 6MWD [464 (406, 538) m vs. 532 (470, 575) m, P = 0.028], higher disease severity score (P = 0.017), were more likely to have decreased oxygen saturation after COVID-19 infection.

CONCLUSION:

aPAP patients with poor baseline respiration have a higher probability of hypoxia after COVID-19 infection, but fatal events were rare.

• Authors: Chuanxin Duan, Wangji Zhou, Miaoyan Zhang, Chongsheng Cheng, Wenshuai Xu, Jinrong Dai, Shuzhen Meng, Keqi Chen, Yang Zhao, Song Liu, Shao-Ting Wang, Yanli Yang, Kai-Feng Xu, Xinlun Tian
• Journal: Orphanet journal of rare diseases (Orphanet J Rare Dis) Vol. 18 Issue 1 Pg. 353 (Nov 11 2023) ISSN: 1750-1172 [Electronic] England
• PMID: 37951939 (Publication Type: Journal Article)
• Copyright: © 2023. The Author(s).

Chemical References

• Oxygen

Topics

• Humans
• Pulmonary Alveolar Proteinosis
• COVID-19
• SARS-CoV-2
• Autoimmune Diseases (drug therapy)
• Oxygen