Abstract | PURPOSE: To describe in detail the special features of a previously unappreciated "classic invasive lobular carcinoma" which is confined to the terminal ductal lobular units (TDLUs) and differs considerably from the extensive classic invasive lobular carcinoma, and to suggest specific terminology. METHOD: RESULTS: The imaging biomarkers differentiated two separate disease subgroups, having the same histopathologic diagnosis, classic invasive lobular carcinoma. One of these has the imaging biomarker of extensive architectural distortion with no central tumour mass, occupies the extralobular mesenchyme and has a long-term survival of 56%. The other subgroup forms stellate or circular non-calcified tumour masses usually smaller than 20 mm, which appear to arise in the intralobular mesenchyme, and has a significantly better long-term survival of 84%. CONCLUSIONS: There is a striking difference between the subgross histopathology and the mammographic appearance (imaging biomarkers) of two breast malignancies having the same histopathologic diagnosis, "classic invasive lobular carcinoma". The large difference in the long-term outcome of these two tumour types is even more striking. Using the same specific term, "classic invasive lobular carcinoma", to describe these two separate entities can adversely affect management decisions.
|
Authors | László Tabár, Peter B Dean, Amy Ming-Fang Yen, Wendy Yi-Ying Wu, Miklós Tarján, F Lee Tucker, Tony Hsiu-Hsi Chen, András Vörös |
Journal | European journal of radiology
(Eur J Radiol)
Vol. 168
Pg. 111119
(Nov 2023)
ISSN: 1872-7727 [Electronic] Ireland |
PMID | 37813006
(Publication Type: Journal Article)
|
Copyright | Copyright © 2023 Elsevier B.V. All rights reserved. |
Chemical References |
|
Topics |
- Humans
- Female
- Carcinoma, Lobular
(diagnostic imaging, pathology)
- Carcinoma in Situ
(pathology)
- Breast Neoplasms
(pathology)
- Mammography
- Calcinosis
- Biomarkers
- Carcinoma, Ductal, Breast
(pathology)
|