Adenosine signaling as target in cardiovascular pharmacology.

Abstract

Increasing evidence demonstrated the relevance of adenosine system in the onset and development of cardiovascular diseases, such as hypertension, myocardial infarct, ischemia, hypertension, heart failure, and atherosclerosis. In this regard, intense research efforts are being focused on the characterization of the pathophysiological significance of adenosine, acting at its membrane receptors named A1, A2A, A2B, and A3 receptors, in cardiovascular diseases. The present review article provides an integrated and comprehensive overview about current clinical and pre-clinical evidence about the role of adenosine in the pathophysiology of cardiovascular diseases. Particular attention has been focused on current scientific evidence about the pharmacological ligands acting on adenosine pathway as useful tools to manage cardiovascular diseases.

• Authors: Luca Antonioli, Matteo Fornai, Carolina Pellegrini, Pál Pacher, György Haskó
• Journal: Current opinion in pharmacology (Curr Opin Pharmacol) Vol. 71 Pg. 102393 (08 2023) ISSN: 1471-4973 [Electronic] England
• PMID: 37450948 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2023 Elsevier Ltd. All rights reserved.

Chemical References

• Adenosine
• Receptor, Adenosine A2A
• Receptor, Adenosine A2B

Topics

• Humans
• Adenosine (pharmacology)
• Cardiovascular Diseases (drug therapy)
• Hypertension
• Receptor, Adenosine A2A
• Receptor, Adenosine A2B (metabolism)