Phthalocyanine-Blue Nanoparticles for the Direct Visualization of Tumors with White Light Illumination.

Abstract

The current standard of care for colon cancer surveillance relies heavily on white light endoscopy (WLE). However, dysplastic lesions that are not visible to the naked eye are often missed when conventional WLE equipment is used. Although dye-based chromoendoscopy shows promise, current dyes cannot delineate tumor tissues from surrounding healthy tissues accurately. The goal of the present study was to screen various phthalocyanine (PC) dye-loaded micelles for their ability to improve the direct visualization of tumor tissues under white light following intravenous administration. Zinc PC (tetra-tert-butyl)-loaded micelles were identified as the optimal formulation. Their accumulation within syngeneic breast tumors led the tumors to turn dark blue in color, making them clearly visible to the naked eye. These micelles were similarly able to turn spontaneous colorectal adenomas in Apc+/Min mice a dark blue color for easy identification and could enable clinicians to more effectively detect and remove colonic polyps.

• Authors: Ahmad Amirshaghaghi, Wen-Chi Chang, Bonirath Chhay, Ariane R Bartolomeu, Margie L Clapper, Zhiliang Cheng, Andrew Tsourkas
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 15 Issue 28 Pg. 33373-33381 (Jul 19 2023) ISSN: 1944-8252 [Electronic] United States
• PMID: 37395349 (Publication Type: Journal Article)

Chemical References

• phthalocyanine
• Coloring Agents
• Micelles

Topics

• Nanoparticles (chemistry)
• Neoplasms (diagnostic imaging)
• Light
• Coloring Agents (chemistry)
• Micelles
• Male
• Animals
• Mice
• Humans
• Mice, Inbred BALB C
• Cell Line, Tumor