Surgical peri-implantitis treatment with and without guided bone regeneration. A randomized controlled trial.

Abstract

OBJECTIVE:

To evaluate the efficacy of reconstructive peri-implantitis treatment.

MATERIALS AND METHODS:

Forty participants, with peri-implantitis and a contained intraosseous defect, were randomized to access flap (control) or access flap with xenograft and collagen membrane (test). All received systemic antimicrobials. Blinded examiners recorded probing depths (PD), bleeding and suppuration on probing (BOP & SOP), soft tissue levels, and marginal bone levels (MBL) at baseline and 12 months. Patient reported outcomes were recorded. The primary outcome was PD change.

RESULTS:

All 40 participants (40 implants) completed the 12-month study. The mean (standard deviation) PD reduction (deepest site) was 4.2 (1.8) mm in the control and 3.7 (1.9) mm in the test group. MBL gain (deepest site) was 1.7 (1.6) mm in the control and 2.4 (1.4) mm in the test group. Absence of BOP & SOP was observed at 60% of both control and test implants. Buccal recession was 0.9 (1.6) mm in the control and 0.4 (1.1) mm in the test group. A successful outcome (absence of PD ≥ 5 mm with BOP, absence of SOP and absence of progressive bone loss) was achieved for 90% of the control and 85% of test group implants. No statistically significant differences in clinical or radiographic parameters were found between treatment groups. 30% of participants experienced mild gastro-intestinal disturbances. Reporting followed CONSORT guidelines.

CONCLUSION:

Similar clinical and radiographic improvements at 12 months were observed with high levels of patient satisfaction for both the access flap and xenograft covered by collagen membrane groups. Registered clinical trials.gov. ID:NCT03163602 (23/05/2017).

• Authors: Lisa J A Heitz-Mayfield, Fritz Heitz, Bernard Koong, Tom Huang, Paola Chivers
• Journal: Clinical oral implants research (Clin Oral Implants Res) Vol. 34 Issue 9 Pg. 892-910 (Sep 2023) ISSN: 1600-0501 [Electronic] Denmark
• PMID: 37382408 (Publication Type: Randomized Controlled Trial, Journal Article)
• Copyright: © 2023 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.

Chemical References

• Collagen
• Dental Implants

Topics

• Humans
• Peri-Implantitis (surgery, drug therapy)
• Treatment Outcome
• Plastic Surgery Procedures
• Collagen (therapeutic use)
• Bone Regeneration
• Dental Implants