Effects on Diabetic Mice of Consuming Lipid Extracted from Foxtail Millet (Setaria italica): Gut Microbiota Analysis and Serum Metabolomics.

Abstract

Millet and its components have received much extensive attention for their health benefits in mitigating metabolic diseases. Foxtail millet is rich in phytochemicals, including oil. However, the hypoglycemic capacity of foxtail millet oil has yet to be fully investigated. The present study explored the effects of consuming this oil as the lipid extract of foxtail millet (LEFM) on intestinal microbiota composition and metabolic function in diabetic mice. After eight weeks of LEFM supplementation, the blood glucose, insulin resistance index, and lipid accumulation of diabetic mice were significantly decreased. In addition, LEFM feeding modulated gut microbiota composition, reduced the abundance of harmful bacteria (Escherichia-Shigella, Peptococcus, and norank_f_Oscillospiraceae), induced a bloom of probiotics, especially short-chain fatty acid (SCFA)-producing bacteria (Adlercreutzia, Faecalibaculum, and Bifidobacterium), and increased SCFAs concentration. LEFM treatment altered serum metabolite levels, for instance, greatly increasing the levels of l-carnitine and l-glutamine and reducing S-acetyldihydrolipoamide-E and sphingosine. Overall, improvements in gut microbiota and metabolic function were associated with the hypoglycemic potential of LEFM.

• Authors: Han Wang, Qun Shen, Yongxia Fu, Zhenyu Liu, Tong Wu, Chao Wang, Qingyu Zhao
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 71 Issue 26 Pg. 10075-10086 (Jul 05 2023) ISSN: 1520-5118 [Electronic] United States
• PMID: 37347971 (Publication Type: Journal Article)

Chemical References

• Hypoglycemic Agents
• Lipids

Topics

• Animals
• Mice
• Setaria Plant (metabolism)
• Gastrointestinal Microbiome
• Diabetes Mellitus, Experimental (drug therapy)
• Metabolomics
• Hypoglycemic Agents (metabolism)
• Lipids