Consolidative radiation in partial responders/unresectable/recurrent disease after first-line/salvage chemotherapy in poor-risk nonseminomatous germ cell tumor prolongs survival: A new paradigm?

Abstract

The role of radiotherapy (RT) in partial radiographic response (PR)/unresectable has not been evaluated earlier in nonseminomatous germ cell tumor (NSGCT). Can the PR/unresectable be treated with consolidation RT instead of surgery? This approach will allow avoidance of surgical morbidity and be an additional tool for treatment. We report a series of five cases with poor prognosis NSGCT, who were treated with consolidation RT after PR/un-resectable disease and complete serum marker decline. The median survival of these patients was 52 months (range 21-112 months).

• Authors: Sandeep Tiwari, Sushma Agrawal
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) 2023 Jan-Mar Vol. 19 Issue 2 Pg. 457-460 ISSN: 1998-4138 [Electronic] India
• PMID: 37313917 (Publication Type: Case Reports)

Topics

• Humans
• Male
• Neoplasms, Germ Cell and Embryonal (drug therapy, radiotherapy)
• Testicular Neoplasms (drug therapy, radiotherapy)
• Chronic Disease
• Radiation Oncology