Nonseminomatous germ cell tumor

Testicular neoplasms that originate in GERM CELLS, including EMBRYONAL CARCINOMA; TERATOMA, CHORIOCARCINOMA; and YOLK SAC TUMOR. Polymorphisms in the BCL10 gene, and somatic mutations in BRAF and KRAS genes have been identified. OMIM: 273300

Also Known As:

NSGCT Nonseminomatous germ cell tumor; Non-seminomatous germ-cell tumors

Networked: 338 relevant articles (21 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Seminoma
3.	Embryonal Carcinoma
4.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
5.	Brain Neoplasms (Brain Tumor)

Experts

1.	Sheinfeld, Joel: 11 articles (08/2018 - 11/2002)
2.	Foster, Richard S: 7 articles (01/2022 - 03/2007)
3.	Einhorn, Lawrence H: 6 articles (01/2022 - 09/2007)
4.	Bosl, George J: 5 articles (08/2018 - 02/2004)
5.	Carver, Brett S: 5 articles (08/2018 - 07/2005)
6.	Motzer, Robert J: 5 articles (08/2018 - 02/2004)
7.	Fizazi, K: 5 articles (02/2013 - 01/2002)
8.	Beck, Stephen D W: 5 articles (09/2010 - 03/2007)
9.	Jewett, Michael A S: 4 articles (01/2021 - 02/2005)
10.	Bajorin, Dean F: 4 articles (08/2018 - 12/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nonseminomatous germ cell tumor:

1.	Cisplatin (Platino)FDA LinkGeneric 09/01/2004 - "Advances in the management of non-seminomatous germ cell tumors during the cisplatin era: a single-institution experience." 07/01/2009 - "The objective of this study was to evaluate the efficacy and safety of cisplatin-based chemotherapy followed by surgery for patients with a malignant nonseminomatous germ cell tumor (NSGCT) of the mediastinum. " 07/01/2009 - "Cisplatin-based chemotherapy followed by surgery for malignant nonseminomatous germ cell tumor of mediastinum: one institution's experience." 01/01/2008 - "Patients were retrospectively grouped according to a published prognostic score defined by Fossa and colleagues [Fossa SD, Stenning SP, Gerl A, et al. Prognostic factors in patients progressing after cisplatin-based chemotherapy for malignant non-seminomatous germ cell tumors. " 12/01/1996 - "Cisplatin-based combination chemotherapy will cure 70% to 80% of patients with metastatic non-seminomatous germ cell tumors but is associated with the possibility of severe neuro-, oto- and nephro-toxicities. "
2.	Carboplatin (JM8)FDA LinkGeneric 12/01/1996 - "In first-line consolidation treatment of poor-risk non-seminomatous germ-cell tumors, the results of phase II trials with carboplatin-based high-dose therapy are in favor of a survival impact when compared to historical controls. " 01/01/2002 - "Efficient carboplatin single therapy in a mouse model of human testicular nonseminomatous germ cell tumor." 10/01/2003 - "We examined the efficacy of angiostatic thrombospondin-1 (TSP-1), endostatin and combined angiostatic/low dose carboplatin in mice xenografted with human nonseminomatous germ cell tumor. " 01/01/2002 - "Carboplatin single therapy was highly effective in our nonseminomatous germ cell tumor model and it may be examined in future clinical trials in patients with high risk stage I nonseminomatous germ cell cancer for reducing cisplatin based combination therapy induced morbidity. " 06/01/1990 - "A prospective study of four cycles of carboplatin (CBDCA) + etoposide + bleomycin (EBC) was conducted in 32 previously poor-risk nonseminomatous germ cell tumor (GCT) patients and the results compared with past studies. "
3.	Tumor Biomarkers (Tumor Markers)IBA 03/01/2014 - "Re: tumor marker kinetics predict outcome in patients with relapsed disseminated non-seminomatous germ-cell tumors." 02/01/2013 - "Tumor marker kinetics predict outcome in patients with relapsed disseminated non-seminomatous germ-cell tumors." 08/01/2010 - "Predictive value of modeled AUC(AFP-hCG), a dynamic kinetic parameter characterizing serum tumor marker decline in patients with nonseminomatous germ cell tumor." 09/01/1997 - "Furthermore, of 11 cases of nonseminomatous germ cell tumor hydrocele fluids, 3 with negative peripheral tumor marker values had to be reclassified marker positive, of which 2 showed elevated hCG levels and 1 had increased levels of AFP. " 01/01/1993 - "Value of tumor markers in nonseminomatous germ cell tumor of the testis."
4.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 10/01/2020 - "A 22-year-old male was diagnosed with a metastatic nonseminomatous germ cell tumor in the mediastinum with an elevated serum alpha-fetoprotein(AFP)concentration. " 11/17/2016 - "We present the case of a young male with NMC arising in the mediastinum with elevated serum alpha-fetoprotein levels suggestive of an extragonadal nonseminomatous germ-cell tumor. " 01/01/2011 - "A 43-year-old-man was diagnosed as having primary mediastinal nonseminomatous germ cell tumor based on percutaneous biopsy and an elevated serum concentration of alpha-fetoprotein (AFP). " 11/17/2016 - "Nonseminomatous germ cell tumor was suspected due to the young age, location of the tumors, and elevated serum alpha-fetoprotein. " 02/01/2006 - "His alpha-fetoprotein level was 12946.2 ng/mL and the biopsy of the tumor revealed a nonseminomatous germ cell tumor. "
5.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 02/01/1991 - "Nonseminomatous germ cell tumor with very high serum human chorionic gonadotropin." 01/01/1982 - "Among 17 men who had received seemingly curative treatment for unilateral non-seminomatous germ cell tumors for the testis and who had consistently normal serum human chorionic gonadotropin (HCG) levels at a reference laboratory, 7 (41%) had at least one falsely positive commercial serum HCG determination. " 01/01/1992 - "Monitoring of patients with non-seminomatous germ cell tumors of the testis by determination of alpha-fetoprotein and beta-human chorionic gonadotropin levels and by computed tomography." 09/01/1980 - "Serum levels of alpha-fetoprotein and human chorionic gonadotropin were used in the management of 50 consecutive patients with non-seminomatous germ cell tumors of the testis. " 06/01/2017 - "After three cycles of chemotherapy for the mediastinal nonseminomatous germ cell tumor, the serum α-fetoprotein and β-human chorionic gonadotropin levels were normalized. "
6.	PlatinumIBA 01/01/1990 - "In recent years, the prognosis of non-seminomatous germ-cell tumors has been greatly improved by the use of novel chemotherapeutic regimens including platinum derivatives. " 01/01/2016 - "High-Dose Chemotherapy in a Late Relapse, Platinum-Refractory Nonseminomatous Germ Cell Tumor." 05/01/1997 - "The realization that platinum-based chemotherapy could cure most patients with an advanced nonseminomatous germ cell tumor (NSGCT), especially those with minimal disease, led to the introduction of various strategies to decrease the morbidity associated with surgical management. " 01/01/2016 - "Following the advent of platinum-based chemotherapy, Surgery, excepting orchidectomy, has become an adjunct treatment in the management of metastatic non-seminomatous germ cell tumors (NSGCT). " 10/01/2017 - "Durable Response to Immune Checkpoint Blockade in a Platinum-Refractory Patient With Nonseminomatous Germ Cell Tumor."
7.	EndostatinsIBA 10/01/2003 - "We examined the efficacy of angiostatic thrombospondin-1 (TSP-1), endostatin and combined angiostatic/low dose carboplatin in mice xenografted with human nonseminomatous germ cell tumor. "
8.	MIB-1 antibodyIBA 06/01/1995 - "Assessment of proliferation rates using MIB-1 antibody in clinical Stage A nonseminomatous germ-cell-tumor patients may prove helpful in predicting metastatic status.(ABSTRACT TRUNCATED AT 250 WORDS)"
9.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/2020 - "In this study, we present a dynamic case of a 26-year-old male, who had undergone surgical resection and systemic bleomycin treatment for a metastatic nonseminomatous germ cell tumor, and later developed recurrent masses in his posterior mediastinum seen on surveillance imaging. " 12/20/2016 - "Perioperative Morbidity and Mortality Associated With Bleomycin in Primary Mediastinal Nonseminomatous Germ Cell Tumor." 05/01/2006 - "The aim of our study was to assess the feasibility of bleomycin omission from two cycles of adjuvant bleomycin, etoposide and cysplatin (BEP) chemotherapy in patients with clinical stage I non-seminomatous germ cell tumors (NSGCT). " 06/01/1990 - "A prospective study of four cycles of carboplatin (CBDCA) + etoposide + bleomycin (EBC) was conducted in 32 previously poor-risk nonseminomatous germ cell tumor (GCT) patients and the results compared with past studies. " 01/01/2008 - "One cycle of bleomycin, etoposide and cisplatin effectively decreases the risk of relapse in patients with high risk stage I nonseminomatous germ cell tumor of the testis. "
10.	Etoposide (VP 16)FDA LinkGeneric 06/01/1988 - "[Role of VP 16 in the treatment of non-seminomatous germ cell tumors of the testis]." 03/01/1997 - "Four cycles of etoposide and cisplatin could yield inferior results compared to 3 cycles of BEP in patients with good risk nonseminomatous germ cell tumor of the testis. " 05/01/2006 - "The aim of our study was to assess the feasibility of bleomycin omission from two cycles of adjuvant bleomycin, etoposide and cysplatin (BEP) chemotherapy in patients with clinical stage I non-seminomatous germ cell tumors (NSGCT). " 07/01/2009 - "One had stage 1 nonseminomatous germ cell tumor (NSGCT) at the age of 32 in 1990 and developed marker relapse on surveillance and had chemotherapy using cisplatin and etoposide for four cycles. " 02/01/2004 - "To assess the long-term relapse-free survival and overall survival of patients with stage II nonseminomatous germ cell tumor (NSGCT) who received two cycles of adjuvant etoposide and cisplatin (EP) after primary retroperitoneal lymph node dissection. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/01/2000 - "As expected, the type of chemotherapy we used, to treat non-seminomatous germ-cell tumors proved to be highly effective for seminomatous types, as well. " 01/01/1990 - "Chemotherapy has dramatically improved the prognosis of non-seminomatous germ cell tumors (NSGCT). " 02/01/2010 - "Controversy arises regarding the optimal management of patients with nonseminomatous germ cell tumor (NSGCT) who achieve a serologic and radiographic complete remission (CR) to systemic chemotherapy. " 12/01/2007 - "Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor." 06/01/2006 - "The goal of our study was to assess the feasibility of usage of chemotherapy regimens with reduced intensity in subgroups of selected patients with good-prognosis metastatic nonseminomatous germ cell tumor (NSGCT) of the testis. "
2.	Lymph Node Excision (Lymph Node Dissection) 01/01/2018 - "We determined the tolerability, safety and efficacy of laparoscopic retroperitoneal lymph node dissection in patients with stage I nonseminomatous germ cell tumor of the testis at a high volume center. " 01/01/2001 - "Transperitoneal laparoscopic para-aortic lymph node dissection has been reported with good results for early stage nonseminomatous germ cell tumor of the testis. " 05/01/2004 - "Although laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumor is feasible, the technique and efficacy of this procedure require further investigation." 03/01/2004 - "To evaluate the feasibility, morbidity, and long-term oncologic efficacy of laparoscopic retroperitoneal lymph node dissection (L-RPLND) in patients with nonseminomatous germ cell tumor (NSGCT). " 01/01/2021 - "Racial and socioeconomic disparities in retroperitoneal lymph node dissection and survival in nonseminomatous germ cell tumor: A population-based study."
3.	Radiotherapy 08/01/2013 - "The efficacy of radiotherapy, especially intensity-modulated radiation therapy, for a nonseminomatous germ cell tumor is discussed. " 01/01/2023 - "The role of radiotherapy (RT) in partial radiographic response (PR)/unresectable has not been evaluated earlier in nonseminomatous germ cell tumor (NSGCT). " 10/01/2021 - "Radiotherapy role in non-seminomatous germ cell tumors, radiobiological and technical issues of an unexplored scenario." 01/01/2019 - "Stereotactic Ablative Radiotherapy (SAbR) in the Setting of Metastatic Nonseminomatous Germ Cell Tumor of Testis." 08/01/2013 - "We report the case of a 41-year-old man with a late recurrence of nonseminomatous germ cell tumor, which was successfully treated with intensity-modulated radiation therapy. "
4.	Combination Drug Therapy (Combination Chemotherapy) 10/01/2023 - "The majority of patients with advanced nonseminomatous germ-cell tumor are cured with combination chemotherapy and surgical resection of residual disease when appropriate. " 01/01/1981 - "The value of AFP and HCG half lives in predicting the efficacy of combination chemotherapy in patients with non-seminomatous germ cell tumors of the testis." 01/01/1989 - "Combination chemotherapy in malignant non-seminomatous germ-cell tumors: results of a cooperative study of the German Society of Pediatric Oncology (MAKEI 83)." 02/01/1983 - "From the above results, it was considered that combination chemotherapy (BOM and COM) can be an alternative treatment to the conventional retroperitoneal node dissection and radiation therapy for Stage I non-seminomatous germ cell tumors." 12/01/1996 - "Cisplatin-based combination chemotherapy will cure 70% to 80% of patients with metastatic non-seminomatous germ cell tumors but is associated with the possibility of severe neuro-, oto- and nephro-toxicities. "
5.	Therapeutics 11/01/2009 - "This review describes the toxic effects of therapy and the efforts aiming to overcome toxicity and improve treatment efficacy, focusing on the trials which form the basis of current standard treatment of non-seminomatous germ cell tumors." 09/15/1984 - "We undertook a study to determine whether scrutiny of AFP glycosylation heterogeneity in patients with non-seminomatous germ cell tumors would provide information useful in diagnosis, staging, prognosis, or monitoring for recurrence of disease following therapy. " 01/01/2020 - "National management trends in clinical stage IIA nonseminomatous germ cell tumor (NSGCT) and opportunities to avoid dual therapy." 10/01/2013 - "[A case of a nonseminomatous germ cell tumor responding to MEA therapy]." 06/10/1994 - "[Stage-oriented therapy in non-seminomatous germ cell tumors]."