[A Case of Aldosterone-Producing Adrenocortical Carcinoma].

Abstract

A 59-year-old man presented with high blood pressure, hypokalemia and muscle weakness. His aldosterone/renin ratio was high and plasma renin activity was low. Computed tomography (CT) showed a heterogeneous left adrenal mass. Primary aldosteronism was diagnosed and laparoscopic left adrenalectomy was performed. The pathological diagnosis was adrenocortical carcinoma with positive surgical margins. He underwent radiotherapy and mitotane as adjuvant therapies. Subsequently, CT revealed multiple metastases, in the liver and retroperitoneum. After six courses of EDP (a combination of etoposide, doxorubicin and cisplatin), CT showed widespread metastases in the retroperitoneum and he chose to receive the best supportive care. Aldosterone-producing adrenocortical carcinoma is exceedingly rare. To the best of our knowledge, only67 cases have been reported. Complete resection is needed to improve prognosis and this was not achieved in our case. We therefore recommend careful selection of the operative procedure.

• Authors: Hiroki Oshiro, Yousuke Shimizu, Ryota Nakayasu, Noriaki Utsunomiya, Cheol Son, Kazuo Tsuji, Satsuki Asai, Hiroki Katsushima, Misa Ishihara, Kimio Hashimoto, Sojun Kanamaru
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 69 Issue 5 Pg. 131-135 (May 2023) ISSN: 0018-1994 [Print] Japan
• PMID: 37312493 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Aldosterone
• Renin
• Mitotane

Topics

• Male
• Humans
• Middle Aged
• Adrenocortical Carcinoma (diagnostic imaging, surgery)
• Aldosterone
• Renin
• Mitotane
• Adrenal Cortex Neoplasms (diagnostic imaging, surgery)