Since the beginning of SESN
protein development, they have attracted highly progressive attention due to their regulatory role in multiple signalling pathways. Through their
antioxidant activity and autophagy regulation implication, they can function as powerful
antioxidants to reduce oxidative stress in cells.
SESN proteins received special attention in the field of regulation of
reactive oxygen species level in the cell and its interplay with signalling pathways determining energy and nutrient homeostasis. Since perturbations in these pathways are implicated in
cancer onset and development, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the impact of
SESN proteins on anti-
cancer therapy based on naturally occurring compounds and conventionally used drugs that influence oxidative stress and autophagy-induced cellular signalling pathways. The significant changes in
reactive oxygen species level and nutrient status in
cancer cells generate subsequent
biological effect through the regulation of SESN-dependent pathways. Thus, SESN may serve as the key molecule for regulating anti-
cancer drugs' induced cellular response.