Combination therapy for painful diabetic neuropathy is safe and effective.

Abstract

The studyTesfaye S, Sloan G, Petrie J, et al. Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. Lancet 2022;400:680-90.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/combination-therapy-for-painful-diabetic-neuropathy-is-safe-and-effective/.

• Authors: Helen Saul, Brendan Deeney, Candace Imison, Solomon Tesfaye
• Journal: BMJ (Clinical research ed.) (BMJ) Vol. 381 Pg. 866 (04 21 2023) ISSN: 1756-1833 [Electronic] England
• PMID: 37085164 (Publication Type: Randomized Controlled Trial, Multicenter Study, Journal Article)
• Copyright: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Chemical References

• Pregabalin
• Analgesics
• Amitriptyline
• Duloxetine Hydrochloride

Topics

• Humans
• Diabetic Neuropathies (drug therapy)
• Pregabalin (therapeutic use)
• Analgesics (therapeutic use)
• Amitriptyline (therapeutic use)
• Duloxetine Hydrochloride (therapeutic use)
• Treatment Outcome
• Double-Blind Method
• Diabetes Mellitus