The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review.

Abstract

The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.

• Authors: Changchao Dong, Gang Tan, Guangyan Zhang, Wei Lin, Guanglin Wang
• Journal: Frontiers in bioengineering and biotechnology (Front Bioeng Biotechnol) Vol. 11 Pg. 1133995 ( 2023) ISSN: 2296-4185 [Print] Switzerland
• PMID: 37064239 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 Dong, Tan, Zhang, Lin and Wang.