Factor XI kinetics after plasma exchange in severe factor XI deficiency.

Abstract

Plasma exchange in a patient with factor XI deficiency allowed the determination of the factor XI disappearance time. The decay curve showed a biphasic pattern with a t1/2 of h. After a loading dose by means of plasma exchange with fresh frozen plasma (FFP) up to a factor XI level of 65%, administration of 0.5 liter FFP every 12 h was necessary to maintain the factor XI concentration between 40 and 60%. The clearances of factor XI, calculated from the results of plasma exchange and from the maintenance dose, correlated very well and showed that the t1/2 of factor XI did not change after surgery. The patient underwent major surgery uneventfully but ultimately died 3 1/2 weeks after operation from cerebral damage due to cardiac arrest, which occurred on the 2nd postoperative day.

• Authors: I R Nováková, C A van Ginneken, H W Verbruggen, C Haanen
• Journal: Haemostasis (Haemostasis) Vol. 16 Issue 1 Pg. 51-6 ( 1986) ISSN: 0301-0147 [Print] Switzerland
• PMID: 3699586 (Publication Type: Case Reports, Journal Article)

Chemical References

• Factor XI

Topics

• Factor XI (metabolism)
• Factor XI Deficiency (blood, therapy)
• Half-Life
• Humans
• Kinetics
• Male
• Metabolic Clearance Rate
• Middle Aged
• Plasma Exchange