Novichoks-
organophosphorus compounds belong to the
nerve agents group, constituting the fourth generation of
chemical warfare agents. The tremendous toxicity of Novichoks is assumed to be several times greater than that of
VX, whereas no published experimental research supports this. They were surreptitiously created during the Cold War by the Soviet Union.
Novichok's
toxic action mechanism consists of the inhibition of
acetylcholinesterase activity. The review includes data on treating
poisoning caused by OPs which could be used as guidelines for the
therapy in case of
Novichok exposure and HAZMAT/CBRNE approaches. Novichoks pose a severe threat due to their toxicity; however, there is insufficient information about the identity of A-series
nerve agents. Filling in the missing data gaps will accelerate progress in improving protection against Novichoks and developing optimal
therapy for treating
poisoning casualties. Furthermore, introducing solutions to protect medical personnel in contact with a
hazardous substance increases the chances of saving casualties of HAZMAT/CBRNE incidents.