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VX (EDIM)

irreversible phosphorylating inhibitor; structure

Also Known As:

EDIM; O-ethyl S-(2-diisopropylaminoethyl)methylphosphonothioate; S-(2-diisopropylaminoethyl)ethylmethylphosphonothioate; agent VX; methylphosphonothioic acid S-(2-(bis(1- methylethyl)amino)ethyl) O-ethyl ester

Networked: 246 relevant articles (30 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Organophosphorus Compounds: 163
  - Organothiophosphorus Compounds
    - VX: 246
- Sulfur Compounds: 135
  - Organothiophosphorus Compounds
    - VX: 246

Experts

1.	Sciuto, Alfred M: 6 articles (06/2014 - 01/2006)
2.	Mumford, Helen: 6 articles (03/2013 - 07/2006)
3.	McNeal, Monica M: 5 articles (12/2013 - 01/2002)
4.	McDonough, John H: 5 articles (12/2011 - 04/2003)
5.	Shih, Tsung-Ming: 5 articles (12/2011 - 04/2003)
6.	Gordon, Richard K: 5 articles (05/2007 - 01/2006)
7.	Nambiar, Madhusoodana P: 5 articles (05/2007 - 01/2006)
8.	Mostafa, T: 4 articles (03/2015 - 08/2014)
9.	Lenz, David E: 4 articles (04/2011 - 12/2005)
10.	Rezk, Peter E: 4 articles (03/2007 - 01/2006)

Related Diseases

1.	Poisoning 03/25/2013 - "Intramuscular (i.m.) huBuChE afforded almost complete protection when administered prior to the onset of observable cholinergic signs of VX poisoning, but once signs of poisoning became evident the efficacy of i.m. " 05/15/2010 - "Microdialysis has been used as a tool to study percutaneous poisoning by VX in the anesthetised guinea pig. " 01/01/2008 - "VX Penetration Following Percutaneous Poisoning: A Dermal Microdialysis Study in the Guinea Pig." 03/25/2013 - "These results indicate that percutaneous poisoning with VX requires additional conventional treatment in addition to the current pretreatment regimen. " 03/25/2013 - "Timing of decontamination and treatment in case of percutaneous VX poisoning: a mini review."
2.	Infection 08/20/1995 - "It was found that protection of mice against subsequent infection following a single oral immunization with the murine rotavirus strain EDIM was 100% effective for at least 14 months, most of the lifetime of a mouse. " 12/20/1995 - "The importance of antibody and CD8+ cells in resolution of murine rotavirus (EDIM) infection and protection against reinfection was examined with two strains of B-cell-deficient mice. " 10/01/1990 - "Thus, this strain of EDIM caused consistent infection of previously uninoculated neonatal and adult BALB/c mice and produced homotypic but not heterotypic protection against reinfection." 02/01/2010 - "This study used an in vivo mouse model to analyze the response of dendritic cells (DCs) in Peyer's patches (PPs) within the first 48 h of infection with the wild-type murine rotavirus EDIM (EDIM(wt)). " 02/01/1994 - "We conclude that the SA-11 model follows an infection pattern similar to Epizootic Diarrhoea of Infant Mice (EDIM) and propose to study immunological parameters as young susceptible animals mature into adult resistant ones."
3.	Diarrhea 01/01/2000 - "Litters were orally challenged with the SA11 strain (P5B[2], G3) or with the murine rotavirus strain EDIM (P10[16], G3) to verify the degree of protection against diarrhea induced in the newborns. " 06/01/1980 - "Natural epizootic diarrhea of infant mice (EDIM): a light and electron microscope study." 05/19/2014 - "Viral shedding in all mice groups diminished in comparison with the control group when challenged with 100 50% diarrhea doses (DD50) of murine rotavirus strain EDIM. " 08/01/2004 - "Mice were infected with mouse hepatitis virus (MHV), mouse parvovirus (MPV), murine rotavirus (agent of epizootic diarrhea of mice [EDIM]), Sendai virus (SV), or Helicobacter spp. All agents were detected using contact sentinels. " 03/01/2004 - "Although EDIM produced more days of diarrhea and was shed in greater quantities in neonatal BALB/c mice, EMcN was shed in much greater quantities in adult BALB/c mice. "
4.	Neoplasms (Cancer) 06/28/2008 - "Ten rabbits with VX(2) tumor were included in this study. " 09/01/2014 - "Pre-surgical SG treatment, neither alone nor combined with Vx was able to slow down the fast evolution of this tumor. " 09/01/2011 - "Vulvar VX is a benign tumor with misleading clinical features. " 08/01/2010 - "VX is a rare benign mucocutaneous neoplasm that typically presents as a solitary lesion with a predilection for the oral cavity, although extra-oral lesions have been reported involving the vulva, scrotum, penis, anal region and extremities. " 12/23/2008 - "Twenty-four New Zealand white rabbits were inoculated with suspension of VX(2) tumor cells in the subarachnoid space via the foramen magnum (experimental group), and 6 rabbits were inoculated with normal saline (control group). "
5.	Rotavirus Infections 05/19/2014 - "Immunized mice were challenged with EDIM rotavirus and protection against rotavirus infection, measured as viral shedding, was evaluated. " 11/01/2001 - "We examined the importance of T cell-independent B cell activity in the resolution of primary murine (EDIM) rotavirus infection in adult mice. " 12/20/1995 - "Following inoculation of one strain (JHD), rotavirus infection was resolved within days, but when later reinoculated with EDIM, these mice again shed rotavirus. " 11/01/1994 - "Using an adult mouse model to study active immunity against rotavirus infection, it was previously shown that oral immunization with some, but not all, animal rotavirus strains induced protection against subsequent infection following oral challenge with the murine rotavirus strain EDIM. " 12/20/1995 - "Finally, when microMT mice were depleted of CD8+ cells before the initial EDIM infection, gradual resolution of rotavirus shedding was still observed, suggesting a third effector mechanism was also involved in resolution of rotavirus infection in mice."

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Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Vasectomy (Vas Occlusion)
4.	Vagotomy
5.	Transplants (Transplant)