The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach.

Abstract

The aim of this study was to characterize the oral discourse of CBS patients and to verify whether measures obtained during a semi-spontaneous speech production could differentiate CBS patients from controls. A second goal was to compare the performance of patients with CBS probably due to Alzheimer's disease (CBS-AD) pathology and CBS not related to AD (CBS-non-AD) in the same measures, based on the brain metabolic status (FDG-PET) and in the presence of amyloid deposition (amyloid-PET). Results showed that CBS patients were significantly different from controls in speech rate, lexical level, informativeness, and syntactic complexity. Discursive measures did not differentiate CBS-AD from CBS-non-AD. However, CBS-AD displayed more lexical-semantic impairments than controls, a profile that is frequently reported in patients with clinical AD and the logopenic variant of primary progressive aphasia (lvPPA). CBS-non-AD presented mainly with impairments related to motor speech disorders and syntactic complexity, as seen in the non-fluent variant of PPA.

• Authors: Isabel Junqueira de Almeida, Marcela Lima Silagi, Maria Teresa Carthery-Goulart, Jacy Bezerra Parmera, Mario Amore Cecchini, Artur Martins Coutinho, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Eliane Schochat
• Journal: Brain sciences (Brain Sci) Vol. 12 Issue 12 (Dec 12 2022) ISSN: 2076-3425 [Print] Switzerland
• PMID: 36552165 (Publication Type: Journal Article)