Diet containing stearic acid increased food intake in mice by reducing serum leptin compared with oleic acid.

Abstract

In today's society, obesity is becoming increasingly serious, and controlling food intake and maintaining weight balance have become increasingly important. Here, we found that a stearic acid diet can increase food intake without causing obesity in mice compared with an oleic acid diet. Stearic acid increases food intake in mice by reducing serum leptin and increasing NPY neuronal excitability through the JAK2/STAT3 pathway. The impaired anorexic effect of leptin is probably due to repressive cholesterol-oxysterol-LXR-α/SREBP-1c-mediated leptin expression in mouse iWAT. At the same time, we found that stearic acid was not only poorly absorbed by itself in the small intestine but also reduced the entire absorption system of the small intestine. In conclusion, we have proven that a stearic acid diet can increase food intake in mice and avoid obesity, but whether a stearic acid diet could cause adverse reactions in the body remains to be studied.

• Authors: Shuqing Zhu, Xiaohua Feng, Xiajie Feng, Kailai Xie, Yongxiang Li, Lvshuang Chen, Yingfen Mo, Jingwen Liang, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Qingyan Jiang, Lina Wang
• Journal: Food & function (Food Funct) Vol. 14 Issue 2 Pg. 990-1002 (Jan 23 2023) ISSN: 2042-650X [Electronic] England
• PMID: 36545693 (Publication Type: Journal Article)

Chemical References

• Leptin
• Oleic Acid

Topics

• Mice
• Animals
• Leptin
• Oleic Acid
• Diet
• Obesity (metabolism)
• Eating
• Body Weight