Abstract | AIM: MATERIALS AND METHODS: Thirty-five patients (12 males, 23 females) with a clinical diagnosis of CD were included in the study. Intramuscular administration of BoNT-A was performed using either US guidance, or with AL, in two separate therapeutic sessions. The efficacy of BoNT-A administration was assessed with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), Tsui modified scale, Craniocervical Dystonia Questionnaire (CDQ-24) and Clinical Global Impression-Improvement scale (CGI-I). Additionally, patients at therapeutic sessions were digitally recorded and evaluated by two blinded and independent raters. RESULTS: A significant decrease in total TWSTRS, severity subscale TWSTRS, Tsui score, and CDQ-24 was found in both the AL and US group; however, in the TWSTRS disability and pain subscales, a significant decrease was found only in the US group. Moreover, US guided treatment also resulted in a greater decrease in TWSTRS, Tsui score and CDQ-24 compared to anatomical landmarks use only. CONCLUSIONS: US guidance might be helpful in improving the results of BoNT-A injections in cervical dystonia, reducing associated pain and disability; however, more studies are needed to evaluate its clinical efficacy.
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Authors | Małgorzata Tyślerowicz, Jarosław Dulski, Justyna Gawryluk, Jarosław Sławek |
Journal | Toxins
(Toxins (Basel))
Vol. 14
Issue 10
(09 28 2022)
ISSN: 2072-6651 [Electronic] Switzerland |
PMID | 36287943
(Publication Type: Journal Article)
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Chemical References |
- Botulinum Toxins, Type A
- Neuromuscular Agents
- Neurotoxins
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Topics |
- Male
- Female
- Humans
- Torticollis
(diagnostic imaging, drug therapy)
- Botulinum Toxins, Type A
(therapeutic use)
- Neuromuscular Agents
(therapeutic use)
- Neurotoxins
(therapeutic use)
- Prospective Studies
- Treatment Outcome
- Pain
(drug therapy)
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