Abstract | BACKGROUND: There is growing interest in examining objective markers for early identification and behavioral intervention to prevent dementia and mild cognitive impairment in clinical and community settings. OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study involved 865 participants aged ≥ 65 years. A saliva sample was collected in the morning, and the levels of salivary alpha-amylase were assayed. Mild cognitive impairment was evaluated using the Japanese version of the Montreal Cognitive Assessment; a score < 26 was indicative of mild cognitive impairment. A multivariable logistic regression model was used to examine the association of salivary alpha-amylase and mild cognitive impairment after adjusting for age, sex, current drinking status, current smoking status, body mass index, hypertension, diabetes mellitus, physical activity, education, social support, social network, and heart rate variability. RESULTS: CONCLUSION:
|
Authors | N Yamane, A Ikeda, K Tomooka, I Saito, K Maruyama, E Eguchi, K Suyama, A Fujii, T Shiba, K Tanaka, A Kooka, S Nakamura, M Kajita, R Kawamura, Y Takata, H Osawa, A Steptoe, T Tanigawa |
Journal | The journal of prevention of Alzheimer's disease
(J Prev Alzheimers Dis)
Vol. 9
Issue 4
Pg. 752-757
( 2022)
ISSN: 2426-0266 [Electronic] Switzerland |
PMID | 36281680
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Salivary alpha-Amylases
- Biomarkers
|
Topics |
- Humans
- Aged
- Salivary alpha-Amylases
- Cross-Sectional Studies
- Japan
- Mental Status and Dementia Tests
- Cognitive Dysfunction
- Biomarkers
|