Efficacy of Proactive Topical Antihistamine Use in Patients with Seasonal Allergic Conjunctivitis.

Abstract

INTRODUCTION:

Topical antihistamines are often instilled symptomatically to control patients' eye allergy symptoms. The purpose of this study was to evaluate the effectiveness of proactive and as-needed use of antihistamine eye drops in controlling symptoms and to examine whether proactive use may improve quality of life (QOL).

METHODS:

This was a prospective, multicenter, cohort study in Japan. We classified 418 patients who had developed certain symptoms and used antihistamine eye drops for 2 weeks into two groups: those who used the drops at the required frequency at a fixed time (proactive use) and those who used them as-needed. The Japanese Allergic and Conjunctival Diseases Quality of Life Questionnaire (JACQLQ) and Ten-Item Personality Inventory were used to evaluate QOL and personality. Participants' QOL was evaluated using JACQLQ scores after matching of baseline characteristics using propensity score analysis.

RESULTS:

After propensity score matching, 115 "proactive" and 115 "as-needed" patients were analyzed. After treatment, in "as-needed" patients, the overall QOL scale was 1.66 (95% CI 1.55-1.78); in "proactive" patients, the overall QOL scale was 1.34 (95% CI 1.23-1.46) and was significantly improved compared with the "as-needed" patients (analysis of covariance, P = 0.002). Furthermore, proactive use significantly alleviated depression (P = 0.03). This improvement of QOL was independent of improvement of the clinical sign scores.

CONCLUSION:

Proactive use of topical antihistamine may serve as an effective means for improving QOL of patients with seasonal allergic conjunctivitis.

TRIAL REGISTRATION:

University Hospital Medical Information Network (UMIN) 000039554.

• Authors: Atsuki Fukushima, Dai Miyazaki, Hirotsugu Kishimoto, Nobuyuki Ebihara, Proactive Study Group
• Journal: Advances in therapy (Adv Ther) Vol. 39 Issue 12 Pg. 5568-5581 (12 2022) ISSN: 1865-8652 [Electronic] United States
• PMID: 36244054 (Publication Type: Multicenter Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s).

Chemical References

• Histamine Antagonists
• Histamine H1 Antagonists
• Ophthalmic Solutions

Topics

• Humans
• Conjunctivitis, Allergic (drug therapy)
• Quality of Life
• Seasons
• Cohort Studies
• Prospective Studies
• Histamine Antagonists (therapeutic use)
• Histamine H1 Antagonists (therapeutic use)
• Ophthalmic Solutions (therapeutic use)
• Chronic Disease