Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency.

Abstract

We report a case of immune reconstitution inflammatory syndrome (IRIS) after hematopoietic stem cell transplantation (HSCT). The patient had sever bacillus Calmette-Guerin (BCG) vaccine-caused disseminated infection and had received allogeneic HSCT for X-linked severe combined immunodeficiency disease. After HSCT, complicated by treatment-responding veno-occlusive disease and acute graft-versus-host disease, at the time when immunosuppressants were withdrawn, the patient experienced recurrent fever accompanied by elevated inflammatory indicators. After receiving glucocorticoids and ibuprofen, the patient's condition improved, and a diagnosis with BCG-related IRIS was made.

• Authors: Shuangjun Liu, Feng Huo, Guorui Dai, Jie Wu, Maoquan Qin, Huawei Mao, Quan Wang
• Journal: Frontiers in immunology (Front Immunol) Vol. 13 Pg. 960749 ( 2022) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 36225916 (Publication Type: Case Reports)
• Copyright: Copyright © 2022 Liu, Huo, Dai, Wu, Qin, Mao and Wang.

Chemical References

• BCG Vaccine
• Immunosuppressive Agents
• Ibuprofen

Topics

• BCG Vaccine (adverse effects)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Ibuprofen
• Immune Reconstitution Inflammatory Syndrome (diagnosis, etiology)
• Immunosuppressive Agents
• Severe Combined Immunodeficiency