Abstract | BACKGROUND:
Lung cancer is the leading cause of cancer-associated death and the first most diagnosed cancer in the world. More than 2 million new cases are diagnosed and 1.6 million people die due to lung cancer every year. It is urgent to explore novel drugs and approaches for lung cancer treatment. Cinobufotalin is a TCM isolated from dried toad venom, which has been used to treat lung cancer. However, the precise mechanism remains unclear. OBJECTIVE: METHODS: Cell growth was identified by Cell Counting Kit-8 (CCK-8) assay. Besides, ferroptosis of lung cancer cells was determined by intracellular iron content, lactate dehydrogenase (LDH) release and mitochondrial membrane potential. Moreover, RNA levels and proteins were detected by quantitative reverse transcription-PCR (qRT-PCR) and Western blot (WB), respectively. In addition, the regulatory effect of hsa-miR-367-3p on TFRC was confirmed by luciferase reporter assay. RESULTS: CONCLUSION:
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Authors | Junming Huang, Caijiu Deng, Tianshen Guo, Xiaofeng Chen, Peixi Chen, Shaoshan Du, Meizhen Lu |
Journal | Anti-cancer agents in medicinal chemistry
(Anticancer Agents Med Chem)
Vol. 23
Issue 6
Pg. 717-725
( 2023)
ISSN: 1875-5992 [Electronic] Netherlands |
PMID | 36221890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- MIRN367 microRNA, human
- cinobufotalin
- bufogenin
- RNA, Long Noncoding
- MicroRNAs
- Receptors, Transferrin
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Topics |
- Humans
- RNA, Long Noncoding
(genetics)
- Ferroptosis
- MicroRNAs
(genetics)
- Lung Neoplasms
(drug therapy, genetics)
- Receptors, Transferrin
- Cell Proliferation
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