Traumatic brain injuries (TBI) are the greatest source of death in
trauma, and
post-traumatic epilepsy (PTE) is one of the common complications of TBI. Oxidative stress and inflammatory responses play an important role in the process of PTE. Many studies have shown that
Jujuboside A has powerful
antioxidant and anti-inflammatory properties. However, it is not known whether
Jujuboside A has an anti-epileptic effect. The influences of
Jujuboside A in the experimental FeCl3-induced model of PTE were tested by estimating the grade of
seizures and performing behavioral tests. Following that, we detected oxidative stress indicators and inflammatory factors. Additionally, western blotting was used to test the
protein levels of signaling molecules in MAPK pathways. In this study,
Jujuboside A was found to have improved the recognition deficiency and
epilepsy syndromes in the experimental rat model. Moreover, oxidative stress and inflammatory responses induced by FeCl3 injection were relieved by
Jujuboside A. In addition,
Jujuboside A was found to be capable of reducing the increased expression of p-P38 and p-ERK1/2 caused by
iron ions. Collectively, our results demonstrated that
Jujuboside A exhibits an antiepileptogenic effect by alleviating oxidative stress and inflammatory responses via the p38 and ERK1/2 pathways.