Cardiopulmonary and behavioral effects of fentanyl-droperidol in cats.

Abstract

The combination of the narcotic fentanyl (0.4 mg/ml) and the tranquilizer droperidol (20 mg/ml) was injected into 12 healthy adult cats at a rate of 1 ml/9 kg of body weight, sc. Arterial blood pressure, heart rate, respiratory frequency, PaCO2, and PaO2, arterial pH (pHa), and rectal temperature were measured before and 30, 60, 90, and 120 minutes after injection of fentanyl-droperidol. Respiratory frequency was decreased significantly (P less than 0.05) and heart rate increased significantly (P less than 0.05) at all measurement intervals after drug administration. Observed decrements in arterial blood pressure were not significant. Arterial PO2, PCO2, and pH did not change significantly. A significant (P less than 0.05) decrease in body temperature was measured 90 minutes after drug administration. All cats were calm, tractable, and frequently assumed lateral recumbency after administration of fentanyl-droperidol. This maximal tranquil state was determined to be 30 to 60 minutes after drug administration.

• Authors: J L Grandy, R B Heath
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 191 Issue 1 Pg. 59-61 (Jul 01 1987) ISSN: 0003-1488 [Print] United States
• PMID: 3610779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Droperidol
• Fentanyl

Topics

• Animals
• Behavior, Animal (drug effects)
• Blood Gas Analysis (veterinary)
• Blood Pressure (drug effects)
• Body Temperature (drug effects)
• Cats (physiology)
• Droperidol (pharmacology)
• Drug Combinations
• Female
• Fentanyl (pharmacology)
• Heart Rate (drug effects)
• Hydrogen-Ion Concentration
• Male
• Respiration (drug effects)