Protection of zero-valent iron nanoparticles against sepsis and septic heart failure.

Abstract

BACKGROUND:

Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown.

RESULTS:

NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cecal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis.

CONCLUSIONS:

The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury.

• Authors: Daquan Wang, Changyu Wang, Zhenxing Liang, Wangrui Lei, Chao Deng, Xiaoli Liu, Shuai Jiang, Yanli Zhu, Shaofei Zhang, Wenwen Yang, Ying Chen, Yao Qiu, Lingjie Meng, Yang Yang
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 20 Issue 1 Pg. 405 (Sep 05 2022) ISSN: 1477-3155 [Electronic] England
• PMID: 36064371 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Iron

Topics

• Animals
• Heart Failure (metabolism)
• Heart Injuries
• Iron
• Mice
• Myocardium (metabolism)
• Nanoparticles
• Sepsis (metabolism)