Abstract | Background:
Chronic inducible urticaria ( CIndU) constitutes a group of nine different CIndUs in which pruritic wheals and/or angioedema occur after exposure to specific and definite triggers. Histamine released from activated and degranulating skin mast cells is held to play a key role in the pathogenesis of CIndU, but evidence to support this has, as of yet, not been reviewed systematically or in detail. We aim to characterize the role and relevance of histamine in CIndU. Methods: We systematically searched 3 electronic databases (PubMed, Scopus, and Embase) for studies that reported increased serum or skin histamine concentration (direct evidence) or in vitro or ex vivo histamine release (indirect evidence) following trigger exposure. Results: Conclusions:
Histamine released from skin mast cells is a key driver of the development of signs and symptoms and a promising therapeutic target in CIndU.
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Authors | Kanokvalai Kulthanan, Martin K Church, Eva Maria Grekowitz, Tomasz Hawro, Lea Alice Kiefer, Kanyalak Munprom, Yanisorn Nanchaipruek, Chuda Rujitharanawong, Dorothea Terhorst-Molawi, Marcus Maurer |
Journal | Frontiers in immunology
(Front Immunol)
Vol. 13
Pg. 901851
( 2022)
ISSN: 1664-3224 [Electronic] Switzerland |
PMID | 35967442
(Publication Type: Systematic Review)
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Copyright | Copyright © 2022 Kulthanan, Church, Grekowitz, Hawro, Kiefer, Munprom, Nanchaipruek, Rujitharanawong, Terhorst-Molawi and Maurer. |
Chemical References |
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Topics |
- Angioedema
- Chronic Urticaria
- Histamine
- Histamine Release
- Humans
- Urticaria
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