Involucrasin C, Anti-Inflammatory 2,3-Dihydro-1H-Indene Derivative from Chinese Dai Ethnic Medicine Shuteria involucrata.

Abstract

(±)-Involucrasin C (1), a pair of new 2,3-dihydro-1H-indene enantiomers, along with an enantiomeric analog (2), were isolated from Shuteria involucrata. Their structures were established by the basis of comprehensive spectroscopic data analysis and X-ray crystallographic diffraction. Both 1 and 2 significantly inhibited the secretion of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β, suggesting that these two natural 2,3-dihydro-1H-indene derivatives may be active components of S. involucrata and may block inflammation in the initial stage.

• Authors: Xiao-Hong Li, Feng Huang, Bin-Ruo Zhang, Wen-Hong Tan, Afsar Khan, Zhou Zhi-Hong, Lu Liu, Zhu-Ya Yang
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 19 Issue 9 Pg. e202200188 (Sep 2022) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 35922378 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley-VHCA AG, Zurich, Switzerland.

Chemical References

• Anti-Inflammatory Agents
• Cytokines
• Indenes
• Interleukin-6
• Tumor Necrosis Factor-alpha
• indene

Topics

• Anti-Inflammatory Agents (chemistry, pharmacology)
• China
• Cytokines
• Indenes (chemistry)
• Interleukin-6
• Tumor Necrosis Factor-alpha