Serum proteomic profiling of rheumatoid arthritis-interstitial lung disease with a comparison to idiopathic pulmonary fibrosis.

Abstract

Although interstitial lung disease (ILD) causes significant morbidity and mortality in rheumatoid arthritis (RA), it is difficult to predict the development or progression of ILD, emphasising the need for improved discovery through minimally invasive diagnostic tests. Aptamer-based proteomic profiling was used to assess 1321 proteins from 159 patients with rheumatoid arthritis with interstitial lung disease (RA-ILD), RA without ILD, idiopathic pulmonary fibrosis and healthy controls. Differential expression and gene set enrichment analyses revealed molecular signatures that are strongly associated with the presence and severity of RA-ILD and provided insight into unexplored pathways of disease. These warrant further study as non-invasive diagnostic tools and future therapeutic targets.

• Authors: Xiaoping Wu, Yunju Jeong, Sergio Poli de Frías, Imaani Easthausen, Katherine Hoffman, Clara Oromendia, Shahrad Taheri, Anthony J Esposito, Luisa Quesada Arias, Ehab A Ayaub, Rie Maurer, Ritu R Gill, Hiroto Hatabu, Mizuki Nishino, Michelle L Frits, Christine K Iannaccone, Michael E Weinblatt, Nancy A Shadick, Paul F Dellaripa, Augustine M K Choi, Edy Y Kim, Ivan O Rosas, Fernando J Martinez, Tracy J Doyle
• Journal: Thorax (Thorax) Vol. 77 Issue 10 Pg. 1041-1044 (10 2022) ISSN: 1468-3296 [Electronic] England
• PMID: 35907639 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Topics

• Humans
• Proteomics
• Lung Diseases, Interstitial (complications)
• Idiopathic Pulmonary Fibrosis (genetics, complications)
• Arthritis, Rheumatoid (genetics, complications)