The first report of the Italian Migraine Registry (I-GRAINE).

Abstract

Italian Migraine Registry (I-GRAINE) is a multicenter (n = 38), prospective, observational, non-interventional study aimed at providing big data on migraine to ensure proper clinical disease management, according to scientific, and sustainability criteria. We enrolled consecutive patients affected by episodic or chronic migraine according to the systematic random method. Information on sociodemographic characteristics, lifestyle, migraine features, patient's journey, and healthcare resource use were gathered using face-to-face interviews.On the date of 31 December 2021, we enrolled 231 patients at 12 headache centers. Most of them were women (84.4%), with high migraine frequency (9.6 ± 6.9 days/month) and severe disability (MIDAS score: 43.0 ± 40.8; HIT-6 score: 60.4 ± 10.6). Only a minority of patients (38.1%) had previously visited a headache center.A clear-cut difference emerged in the proportion of responders to nonspecific acute treatments (43.5-66.7%) compared to triptans (76.3%) and in responders to unspecific prophylaxis (5.4-35%) compared to anti-CGRP monoclonal antibodies (69.2-78.6%). Most patients underwent ≥ 1 specialist visit (66.9%) or diagnostic investigation (77.4%) over the last 3 years-mostly subsidized by our national health system-inappropriate in 64.9% and 25% of the cases, respectively.The I-GRAINE registry is expected to provide a large and exponentially increasing collection of clinical, biological, and epidemiologic information and will contribute to moving migraine out of the shadow cone of marginalization, which has been often relegated up to now.

• Authors: Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Stefania Proietti, Carlo Tomino, Stefano Bonassi, Italian Migraine Registry Study Group
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 43 Issue 9 Pg. 5725-5728 (Sep 2022) ISSN: 1590-3478 [Electronic] Italy
• PMID: 35802219 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2022. Fondazione Società Italiana di Neurologia.

Chemical References

• Tryptamines

Topics

• Female
• Headache
• Humans
• Male
• Migraine Disorders (diagnosis, drug therapy, epidemiology)
• Prospective Studies
• Registries
• Tryptamines (therapeutic use)