Neural Correlates of Optimal Deep Brain Stimulation for Cervical Dystonia.

Abstract

A total of 15 individuals with cervical dystonia and good outcome after pallidal deep brain stimulation underwent resting-state functional magnetic resonance imaging under three conditions: stimulation using a priori clinically determined optimal settings (ON-Op), non-optimal settings (ON-NOp), and stimulation off (OFF). ON-Op > OFF and ON-Op > ON-NOp were both associated with significant deactivation within sensorimotor cortex (changes not seen with ON-NOp > OFF). Brain responses to stimulation were related to individual long-term clinical improvement (R = 0.73, R2  = 0.53, p = 0.001). The relationship was consistent when this model included four additional patients with generalized or truncal dystonia. These findings highlight the potential for immediate imaging-based biomarkers of clinical efficacy. ANN NEUROL 2022;92:418-424.

• Authors: Aaron Loh, Gavin J B Elias, Jürgen Germann, Alexandre Boutet, Dave Gwun, Kazuaki Yamamoto, Can Sarica, Paula Azevedo, Ajmal Zemmar, Jessica Pinto, Asma Naheed, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Andres M Lozano, Alfonso Fasano
• Journal: Annals of neurology (Ann Neurol) Vol. 92 Issue 3 Pg. 418-424 (09 2022) ISSN: 1531-8249 [Electronic] United States
• PMID: 35785489 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 American Neurological Association.

Topics

• Brain
• Deep Brain Stimulation (methods)
• Globus Pallidus (physiology)
• Humans
• Torticollis (diagnostic imaging, therapy)
• Treatment Outcome