Abstract | PURPOSE: PATIENTS AND METHODS: Between July 2018 and April 2021, 36 consecutive patients ≥ 18 years old with 367 metastases who received SIMT SRS at UPMC Hillman Cancer San Pietro Hospital, Rome, were retrospectively evaluated. SRS plans were created using the commercial software Elements MBM SRS (Version 1.5 and 2.0). Median cumulative gross tumor volume (GTV) and planning tumor volume (PTV) were 1.33 cm3 and 3.42 cm3, respectively. All patients were replanned using HA automated software. Extracted dosimetric parameters included mean dose (Dmean) to the healthy brain, volumes of the healthy brain receiving more than 5, 8,10, and 12 Gy (V5Gy, V8Gy, V10Gy and V12Gy), and doses to hippocampi. RESULTS: Both techniques resulted in high-quality treatment plans, although Element MBM DCAT plans performed significantly better than HA VMAT plans, especially in cases of more than 10 lesions). Median V12Gy was 13.6 (range, 1.87-45.9) cm3 for DCAT plans and 18.5 (2.2-62,3) cm3 for VMAT plans (p < 0.0001), respectively. Similarly, V10Gy, V8Gy, V5Gy (p < 0.0001) and median dose to the normal brain (p = 0.0001) were favorable for DCAT plans. CONCLUSIONS: Both Elements MBM and HA systems were able to generate high-quality plans in patients with up to 25 brain metastases. DCAT plans performed better in terms of normal brain sparing, especially in patients with more than ten lesions and limited total tumor volume.
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Authors | Giorgio Hamid Raza, Luca Capone, Paolo Tini, Martina Giraffa, Piercarlo Gentile, Giuseppe Minniti |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 17
Issue 1
Pg. 116
(Jul 01 2022)
ISSN: 1748-717X [Electronic] England |
PMID | 35778741
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |
Topics |
- Adolescent
- Brain Neoplasms
(radiotherapy)
- Humans
- Radiometry
- Radiosurgery
- Radiotherapy, Conformal
- Retrospective Studies
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