Abstract | BACKGROUND: SUBJECTS AND METHODS: Fifty-two male PTSD outpatients on stable combination treatment with SSRI and benzodiazepines, with persistent sleep disturbances not responding to prescription of zolpidem, flurazepam, nitrazepam, promazine, and levopromazine, were assessed for sleep disturbances improvements after prescription of quetiapine in the evening. Each patient met both ICD-10 and DSM-IV criteria for PTSD. Psychiatric comorbidity and premorbidity were excluded using the Mini-International Neuropsychiatric Interview (MINI). Improvement on the CAPS recurrent distressing dream item, reduction in the amount of time needed to fall asleep, prolongation of sleep duration, and reduction in average number of arousals per night in the last 7 days before the assessment period were used as efficacy measures. RESULTS: All sleep-related parameters improved significantly at the end of a five-week follow-up: sleep duration increased by one hour (p<0.001), sleep latency decreased by 52.5 minutes (p<0.001), median number of arousals per night decreased from two to one (p<0.001), CAPS recurrent distressing dream item median decreased from five to four (p<0.001), and the number of patients dissatisfied with their sleep quality and quantity decreased from 45 to two (p<0.001). CONCLUSION:
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Authors | Maja Vilibić, Vjekoslav Peitl, Maja Živković, Suzana Vlatković, Ivana Ljubičić Bistrović, Rudolf Ljubičić, Ana Matošić, Dalibor Karlović |
Journal | Psychiatria Danubina
(Psychiatr Danub)
Vol. 34
Issue 2
Pg. 245-252
( 2022)
ISSN: 0353-5053 [Print] Croatia |
PMID | 35772134
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Hypnotics and Sedatives
- Benzodiazepines
- Quetiapine Fumarate
- Zolpidem
- Nitrazepam
- Methotrimeprazine
- Flurazepam
- Promazine
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Topics |
- Antipsychotic Agents
(pharmacology, therapeutic use)
- Benzodiazepines
(therapeutic use)
- Flurazepam
(pharmacology, therapeutic use)
- Humans
- Hypnotics and Sedatives
(therapeutic use)
- Male
- Methotrimeprazine
(pharmacology, therapeutic use)
- Nitrazepam
(pharmacology, therapeutic use)
- Promazine
(pharmacology, therapeutic use)
- Quetiapine Fumarate
(pharmacology, therapeutic use)
- Sleep
(physiology)
- Sleep Wake Disorders
(drug therapy, etiology)
- Stress Disorders, Post-Traumatic
(complications, drug therapy, psychology)
- Zolpidem
(pharmacology, therapeutic use)
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