Different
cancer types not only have common characteristics but also have their own characteristics respectively. The mechanism of these specific and common characteristics is still unclear. Pan-
cancer analysis can help understand the similarities and differences among
cancer types by systematically describing different patterns in
cancers and identifying
cancer-specific and
cancer-common molecular
biomarkers. While long non-coding RNAs (lncRNAs) are key
cancer modulators, there is still a lack of pan-
cancer analysis for
lncRNA methylation dysregulation. In this study, we integrated
lncRNA methylation,
lncRNA expression and
mRNA expression data to illuminate specific and common
lncRNA methylation patterns in 23
cancer types. Then, we screened aberrantly methylated lncRNAs that negatively regulated
lncRNA expression and mapped them to the
ceRNA relationship for further validation. 29 lncRNAs were identified as diagnostic
biomarkers for their corresponding
cancer types, with
lncRNA AC027601 was identified as a new KIRC-associated
biomarker, and
lncRNA ACTA2-AS1 was regarded as a carcinogenic factor of KIRP. Two lncRNAs HOXA-AS2 and AC007228 were identified as pan-
cancer biomarkers. In general, the
cancer-specific and
cancer-common
lncRNA biomarkers identified in this study may aid in
cancer diagnosis and treatment.