Abstract | BACKGROUND:
Gallstones may result in inflammation, altered bile flow, and changes in metabolic hormone levels, thereby increasing cancer risk. However, previous studies for gallstones and cancers of the liver, biliary tract and pancreas in the U.S. were relatively limited. METHODS: We followed 115,036 women from the Nurses' Health Study (1982-2012) and 49,729 men from the Health Professionals Follow-up Study (1986-2012). History of gallstones, including with or without performed cholecystectomy, was reported at baseline and updated through biennial questionnaires. The Cox proportional hazard regression model was used to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs). RESULTS: CONCLUSIONS:
Gallstones were associated with a higher risk of cancers of the liver, biliary tract and possibly pancreas.
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Authors | Xiao Luo, Wanshui Yang, Amit D Joshi, Kana Wu, Tracey G Simon, Chen Yuan, Lina Jin, Lu Long, Mi Na Kim, Chun-Han Lo, Xing Liu, Thomas A Abrams, Brian M Wolpin, Andrew T Chan, Edward L Giovannucci, Xuehong Zhang |
Journal | British journal of cancer
(Br J Cancer)
Vol. 127
Issue 6
Pg. 1069-1075
(10 2022)
ISSN: 1532-1827 [Electronic] England |
PMID | 35715632
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
Topics |
- Biliary Tract
- Biliary Tract Neoplasms
(epidemiology)
- Female
- Follow-Up Studies
- Gallstones
(complications, epidemiology)
- Humans
- Liver Neoplasms
- Male
- Pancreas
- Pancreatic Neoplasms
(epidemiology)
- Prospective Studies
- Risk Factors
- Pancreatic Neoplasms
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