Abstract | BACKGROUND: METHODS: We enrolled nine BA patients in this study. All patients received intravenous ICG injections before surgery and underwent Kasai operation. With a fluorescence imaging system (Nanjing Nuoyuan, REAL-IGS FLI-108) to observe the ICG and quantify the ICG fluorescence intensity (ICG-FI) changes of the hepatic portal fibrous tissue and the liver during the operation. As a short-term prognosis assessment, we monitored the postoperative ICG metabolism time in stool and used the jaundice-free (TBIL < 2 mg/dl) at 1-3 months after the operation. RESULTS: The average age of the patients at the time of surgery was 73 days. There were no adverse reactions after ICG injection. All patients were observed ICG-FI increased after the dissection of hepatic portal fibrous tissue, and the ICG-FI of the liver decreased during the operation. They all received standardized treatment after surgery. Four patients completely metabolized ICG within about two weeks (no fluorescence detected in stool), and the other five were longer than two weeks. Five patients achieved a jaundice-free outcome in the short-term postoperatively, and the other four did not. CONCLUSIONS: It is feasible to quantify ICG-FI in real-time to evaluate the anatomical degree of hepatic portal fibrous tissue in BA. The variations of ICG-FI in the liver and postoperative ICG metabolism time may be related to prognosis.
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Authors | Jiawei Zhao, Yanan Zhang, Yuyan Jin, Shuangshuang Li, Junmin Liao, Yong Zhao, Yongwei Chen, Jinshi Huang |
Journal | Photodiagnosis and photodynamic therapy
(Photodiagnosis Photodyn Ther)
Vol. 39
Pg. 102960
(Sep 2022)
ISSN: 1873-1597 [Electronic] Netherlands |
PMID | 35691562
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Biliary Atresia
(surgery)
- Humans
- Indocyanine Green
- Jaundice
- Liver
- Optical Imaging
(methods)
- Photochemotherapy
(methods)
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