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CC and CXC chemokines in turbot (Scophthalmus maximus L.): Identification, evolutionary analyses, and expression profiling after Aeromonas salmonicida infection.

Abstract
Chemokines are a superfamily of structurally related cytokines, which exert essential roles in guiding cell migration in development, homeostasis, and immunity. CC and CXC chemokines are the two major subfamilies in teleost species. In this study, a total of seventeen CC and CXC chemokines, with inclusion of twelve CC and five CXC chemokines, were systematically identified from the turbot genome, making turbot the teleost harboring the least number of CC and CXC chemokines among all teleost species ever reported. Phylogeny, synteny, and genomic organization analyses were performed to annotate these genes, and multiple chemokine genes were identified in the turbot genome, due to the tandem duplications (CCL19 and CCL20), the whole genome duplications (CCL20, CCL25, and CXCL12), and the teleost-specific members (CCL34-36, CCL44, and CXCL18). In addition, chemokines were ubiquitously expressed in nine examined healthy tissues, with high expression levels observed in liver, gill, and spleen. Moreover, most chemokines were significantly differentially expressed in gill and spleen after Aeromonas salmonicida infection, and exhibited tissue-specific and time-dependent manner. Finally, protein-protein interaction network (PPI) analysis indicated that turbot chemokines interacted with a few immune-related genes such as interleukins, cathepsins, stats, and TLRs. These results should be valuable for comparative immunological studies and provide insights for further functional characterization of chemokines in teleost.
AuthorsQiang Fu, Jie Hu, Pei Zhang, Yuqing Li, Shoucong Zhao, Min Cao, Ning Yang, Chao Li
JournalFish & shellfish immunology (Fish Shellfish Immunol) Vol. 127 Pg. 82-98 (Aug 2022) ISSN: 1095-9947 [Electronic] England
PMID35690275 (Publication Type: Journal Article)
CopyrightCopyright © 2022 Elsevier Ltd. All rights reserved.
Chemical References
  • Chemokines, CXC
  • Fish Proteins
Topics
  • Aeromonas salmonicida (genetics)
  • Animals
  • Chemokines, CXC (genetics)
  • Fish Diseases
  • Fish Proteins (genetics)
  • Flatfishes (genetics)
  • Gene Expression Profiling (veterinary)
  • Gene Expression Regulation
  • Phylogeny

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