In elderly aged people,
Parkinson's disease is reported as 2nd most prevailing neuro-degenerative disease. Presently
benzothiazole derivatives are gaining attention after showing positive results in various animal models for the investigation of different motor-diseases. In Current work, the 2- (2 Thienyl)
Benzothiazoline is synthesized and its
therapeutic effect was evaluated against
rotenone-induced
Parkinson's disease. It was expected to obtain the positive results in the treatment because thiophen group has been successfully reported in various literature as effective agent in the treatment of cognitive and locomotory disease. So, we used a Parkinson's inducive compound
rotenone and injectedit intraperitoneally. The dose that we were used was 1.5mg/kg and treatment proceeded for 8 days in rats as
rotenone inhibit the functioning of mitochondrial complex I. Administration of 2- (2 Thienyl)
Benzothiazoline (10mg/kg per day) was already started 15 days prior to
rotenone dose injection. The effects of both pre-treatment and without pre-treatment of 2- (2 Thienyl)
Benzothiazoline were assessed by the use of various motor parameters of behavior such as pole test and Kondziela's inverted screen test for checking muscular strength, whereas inclined plane test, open field test and Rota rod test for motor coordination. Pre-treatment with drug reversed the gross motor impairments which were produced by
rotenone. We conclude that 2- (2 Thienyl)
Benzothiazoline, like its other candidate drug also protects against destructive effects of the compound
rotenone and itcan be used as beneficial drug against various
neurodegenerative diseases.