Abstract |
MicroRNAs ( miRNAs) play a crucial role in cancer progression due to their capability to modulate the expression of various target genes. However, given the heterogeneity of tumor cells, miRNAs have been confirmed to exert different regulatory effects. Here, bioinformatic analysis results indicated that expression of miR-330-5p is decreased in colorectal cancer (CRC) tissues and inversely correlated with SND1 expression. Notably, ectopic expression of miR-330-5p restrained tumor cell proliferation, migration, and enhance the sensitivity of CRC cells to 5-FU. Moreover, similar phenotypes were substantiated after inhibition of SND1 expression using RNA interference. Conversely, overexpression of SND1 facilitated the malignant phenotypes of CRC cells and restored miR-330-5p-mediated tumor-suppressive activities in CRC cells. Mechanistically, miR-330-5p directly binds to SND1-3'-untranslated region (3'-UTR), thus involving in inhibiting CRC cells proliferation and invasion and promoting apoptosis. Taken together, miR-330-5p may act as a tumor suppressor by targeting the expression of SND1, suggesting that the miR-330-5p/SND1 axis may be a meaningful regulator for CRC intervention.
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Authors | Jiaqiang Deng, Shengpeng Liu, Lili Zhao, Yan Li, Junyang Shi, Hua Zhang, Yuxuan Zhao, Liping Han, Huani Wang, Yan Yan, Hong Zhao, Fangdong Zou |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 615
Pg. 116-122
(07 30 2022)
ISSN: 1090-2104 [Electronic] United States |
PMID | 35609416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- 3' Untranslated Regions
- MIRN330 microRNA, human
- MicroRNAs
- Endonucleases
- SND1 protein, human
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Topics |
- 3' Untranslated Regions
- Apoptosis
(genetics)
- Cell Line, Tumor
- Cell Movement
(genetics)
- Cell Proliferation
(genetics)
- Colorectal Neoplasms
(pathology)
- Endonucleases
(genetics, metabolism)
- Gene Expression Regulation, Neoplastic
- Humans
- MicroRNAs
(metabolism)
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