Optimization of photo-biomodulation therapy for wound healing of diabetic foot ulcers in vitro and in vivo.

Abstract

Unclear optical parameters make photo-biomodulation (PBM) difficult to implement in diabetic foot ulcer (DFU) clinically. Here, 12 wavelengths (400-900 nm) were used to conduct PBM to heal DFU wounds in vitro and in vivo. PBM at 10 mW/cm2 and 0.5-4 J/cm2 with all 12 wavelengths promoted proliferation of diabetic wound cells. In a mimic DFU (mDFU) rat model, PBM (425, 630, 730, and 850 nm, and a combination light strategy) promoted mDFU healing. The positive cell proliferation, re-epithelialization, angiogenesis, collagen synthesis, and inflammation were possible mechanisms. The combination strategy had the best effect, which can be applied clinically.

• Authors: Qianqian Chen, Jichun Yang, Huijuan Yin, Yingxin Li, Haixia Qiu, Ying Gu, Hua Yang, Dong Xiaoxi, Shi Xiafei, Bochen Che, Hongxiao Li
• Journal: Biomedical optics express (Biomed Opt Express) Vol. 13 Issue 4 Pg. 2450-2466 (Apr 01 2022) ISSN: 2156-7085 [Print] United States
• PMID: 35519257 (Publication Type: Journal Article)
• Copyright: © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.