Abstract |
Stroke is the central disorder underlined by ischemia-reperfusion (I/R) injury. Eleutheroside E (EE) is administered as the shield in some ischemia tissues with anti-inflammatory action. However, whether EE defends I/R-induced damage in the brain remains unknown. Here, we demonstrated that EE significantly alleviated the cerebral I/R injury and reduced the apoptosis of hippocampal neuron cells in rats. During the anti-apoptosis process, EE significantly upregulated the expression of 5-hydroxytryptamine receptor 2C (Htr2c) gene. Silencing Htr2c expression dramatically weakened the protective effect of EE on I/R-induced apoptosis of rat hippocampal neuron. EE-regulated Htr2c also remarkably inhibited the expression of caspase-3, -6 and -7, thereby suggesting a plausible anti-apoptosis mechanism associated with Htr2c/ caspase axis. These findings elicit the potentially clinical strategy that targets Htr2c to improve outcome of ischemia brain.
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Authors | Zheng Liu, Wenwei Gao, Yuanqin Xu |
Journal | Bioengineered
(Bioengineered)
Vol. 13
Issue 5
Pg. 11718-11731
(05 2022)
ISSN: 2165-5987 [Electronic] United States |
PMID | 35502892
(Publication Type: Journal Article)
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Chemical References |
- Glucosides
- Lignans
- eleutheroside E
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Topics |
- Animals
- Glucosides
(pharmacology, therapeutic use)
- Lignans
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(drug therapy, metabolism)
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