Analysis of Serum Levels of IFN-γ, IL-4, and TNF-α in Patients with Cervicitis Complicated by HPV Infection and Their Clinical Significance.

Abstract

In order to investigate the expression levels of serum IFN-γ, IL-4, and tumor necrosis TNF-α in patients with cervicitis complicated with human papillomavirus (HPV) infection and clinical significance, a retrospective study was conducted on 90 patients with chronic cervicitis complicated by HP V infection who visited our hospital from June 2020 to June 2021, and they are included in the research group. According to the degree of HPV infection, the patients are divided into low-risk HPV type group (n = 65 cases) and high-risk HPV type group (n = 25 cases); 50 patients with cervicitis (without HPV infection) who received treatment in our hospital are selected as control group 1. Fifty healthy women who underwent physical examination are selected as the control group 2. The general data of the two groups of patients during hospitalization are collected, and HPV-DNA, IFN-γ, IL-4, and TNF-α are detected in all patients. For patients with cervicitis complicated by HPV infection, the IFN-indexes in the body are significantly decreased, IL-4 and TNF-αare significantly increased, and with the degree of HPV infection, IFN-γ, IL-4, and TNF-α have high diagnostic performance with HPV infection, and there is a significant correlation between the three, which can be used in cervicitis complicated with HPV infection. It is widely used in the early diagnosis and screening of infected patients.

• Authors: Jingxia Li, Yuejun Liu, Jianjun Song, Wenli Liu, Liyuan Zhou, Shucheng Chen
• Journal: Journal of healthcare engineering (J Healthc Eng) Vol. 2022 Pg. 3374655 ( 2022) ISSN: 2040-2309 [Electronic] England
• PMID: 35463689 (Publication Type: Journal Article, Retracted Publication)
• Copyright: Copyright © 2022 Jingxia Li et al.

Chemical References

• IFNG protein, human
• Tumor Necrosis Factor-alpha
• Interleukin-4
• Interferon-gamma

Topics

• Female
• Humans
• Interferon-gamma (blood)
• Interleukin-4 (blood)
• Papillomavirus Infections (blood, complications, diagnosis)
• Retrospective Studies
• Tumor Necrosis Factor-alpha (blood)
• Uterine Cervicitis (blood, complications, diagnosis)