Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry.

Abstract

INTRODUCTION:

Data from the "Trattamento Ormonale nello Scompenso CArdiaco" (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry.

METHODS:

At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM.

RESULTS:

337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV-V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels.

CONCLUSIONS:

Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.

• Authors: Alfredo De Giorgi, Alberto Maria Marra, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo, Francesco Cacciatore, Ciro Maiello, Giuseppe Limongelli, Daniele Masarone, Francesco Perticone, Pasquale Perrone Filardi, Stefania Paolillo, Antonio Mancini, Maurizio Volterrani, Olga Vriz, Roberto Castello, Andrea Passantino, Michela Campo, Pietro Amedeo Modesti, Andrea Salzano, Roberta D'Assante, Michele Arcopinto, Valeria Raparelli, Fabio Fabbian, Angela Sciacqua, Annamaria Colao, Toru Suzuki, Eduardo Bossone, Antonio Cittadini, T.O.S.CA. Investigators
• Journal: Internal and emergency medicine (Intern Emerg Med) Vol. 17 Issue 6 Pg. 1651-1660 (09 2022) ISSN: 1970-9366 [Electronic] Italy
• PMID: 35445917 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• IGF1 protein, human
• Insulin-Like Growth Factor I

Topics

• Adult
• Heart Failure
• Humans
• Insulin-Like Growth Factor I (analysis)
• Kidney Diseases
• Prognosis
• Registries
• Stroke Volume