Pregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study.

Abstract

The epidemiologic literature on associations between urinary phenol concentrations and lipid profiles during pregnancy is limited. We examined whether urinary concentrations of phenol and phenol replacement biomarkers were associated with serum lipid levels among pregnant women. This cross-sectional study included 175 women attending the Massachusetts General Hospital Fertility Center who enrolled in the Environment and Reproductive Health (EARTH) Study between 2005 and 2017 and had data available on urinary phenol biomarkers and serum lipids during pregnancy. We used linear regression models to assess the relationship between groups of urinary phenol and phenol replacement biomarkers and serum lipid levels [total cholesterol, high density lipoprotein (HDL), non-HDL, low-density lipoprotein (LDL) cholesterol, and triglycerides], while adjusting for age at sample collection, pre-pregnancy BMI, education, race, infertility diagnosis, cycle type, number of fetuses, trimester and specific gravity. In adjusted models, pregnant women with urinary propylparaben concentrations in the highest tertile had 10% [22 (95% CI = 5, 40) mg/dL], 12% [19 (95% CI = 2, 36) mg/dL] and 16% [19 (95% CI = 3, 35) mg/dL] higher mean total, non-HDL and LDL cholesterol, respectively, compared to women with concentrations in the lowest tertile. Similar elevations were observed for urinary bisphenol A concentrations. Urinary bisphenol S, benzophenone-3, triclosan, methylparaben, ethylparaben, and butylparaben were unrelated to serum lipids. Among pregnant women, urinary concentrations of bisphenol A and propylparaben were associated with higher serum levels of total, non-HDL and LDL cholesterol.

• Authors: Lidia Mínguez-Alarcón, Lisa Frueh, Paige L Williams, Tamarra James-Todd, Irene Souter, Jennifer B Ford, Kathryn M Rexrode, Antonia M Calafat, Russ Hauser, Jorge E Chavarro, Earth Study Team
• Journal: The Science of the total environment (Sci Total Environ) Vol. 833 Pg. 155191 (Aug 10 2022) ISSN: 1879-1026 [Electronic] Netherlands
• PMID: 35421480 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Benzhydryl Compounds
• Biomarkers
• Parabens
• Phenols
• Triglycerides
• Cholesterol
• bisphenol A

Topics

• Benzhydryl Compounds
• Biomarkers (blood, urine)
• Cholesterol (blood)
• Cross-Sectional Studies
• Female
• Humans
• Parabens
• Phenols (urine)
• Pregnancy (blood, urine)
• Reproductive Health
• Triglycerides (blood)