Prognostic Impact of the Preoperative Systemic Inflammation Score in Patients With Pancreatic Ductal Adenocarcinoma.

Abstract

BACKGROUD:

The systemic inflammation score (SIS), which is based on the preoperative lymphocyte-to-monocyte ratio (LMR) and serum albumin (Alb) level, is a prognostic indicator for several cancer types. However, the prognostic significance of the SIS in pancreatic ductal adenocarcinoma (PDAC) remains unknown.

METHODS:

Seventy-eight patients who underwent radical surgery for PDAC were categorized as follows: SIS 0 (LMR ≥3.51 and Alb ≥4.0 g/dl), n = 26; SIS 1 (LMR <3.51 or Alb <4.0 g/dl), n = 29 and SIS 2 (LMR <3.51 and Alb <4.0 g/dl), n=23.

RESULTS:

The tumour size sequentially increased in SIS 0, 1 and 2 groups. A higher SIS was associated with increased vascular invasion, perineural invasion and surgical margin positivity rate. Recurrence-free survival (RFS) rates between the SIS 1 and 2 groups showed no significant difference However, patients of the SIS 1 and 2 groups had poorer outcomes than those of the SIS 0 group for RFS. Overall survival (OS) rates between the SIS 1 and 2 groups also showed no significant difference. However, patients of the SIS 1 and 2 groups had poorer outcomes than those of the SIS 0 group for OS. The SIS was an independent prognostic factor for RFS and OS.

DISCUSSION:

The SIS is a simplified prognostic factor for patients with PDAC.

• Authors: Tomohiro Iguchi, Norifumi Iseda, Kosuke Hirose, Shinji Itoh, Noboru Harada, Mizuki Ninomiya, Keishi Sugimachi, Takuya Honboh, Takashi Maeda, Noriaki Sadanaga, Hiroshi Matsuura
• Journal: The American surgeon (Am Surg) Vol. 89 Issue 6 Pg. 2213-2219 (Jun 2023) ISSN: 1555-9823 [Electronic] United States
• PMID: 35392670 (Publication Type: Journal Article)

Topics

• Humans
• Prognosis
• Pancreatic Neoplasms (pathology)
• Carcinoma, Pancreatic Ductal (surgery, pathology)
• Inflammation
• Retrospective Studies
• Pancreatic Neoplasms