Abstract | OBJECTIVE: METHODS: RESULTS: Sixteen RCTs, involving 3481 participants, were included. The placebo-controlled and treatment blinded durations ranged from 12 to 24 weeks. Compared with the placebo, bDMARD therapy was associated with significant improvement in HRQoL measures with the 36-item Short Form Survey (SF-36), European Quality of Life-5 Dimensions (EQ-5D), and Ankylosing Spondylitis Quality of Life (ASQoL). The pooled mean differences of changes from baseline for the SF-36 Physical Component Score (PCS), SF-36 Mental Component Score (MCS), EQ-5D, and ASQoL were 4.39 [95% Confidence Interval (CI): 3.24 to 5.54, P < 0.001]; 2.37 (95%-CI: 1.25 to 3.49, P = 0.003); 0.11 (95%-CI: 0.07 to 0.14, P < 0.001); and -2.45 (95%-CI: -3.21 to -1.70, P < 0.001), respectively. Heterogeneity was high (I2 = 79%) among studies reporting SF-36 PCS, and moderate (I2 = 61%, 34%, and 49%) among studies reporting SF-36 MCS, EQ-5D, and ASQoL, respectively. CONCLUSIONS:
Biologic therapy was associated with a significant improvement in quality of life in patients with r- axSpA. The results were consistent among all three measures of HRQoL outcomes.
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Authors | Anh Ho, Ibrahim Younis, Quang A Le |
Journal | Seminars in arthritis and rheumatism
(Semin Arthritis Rheum)
Vol. 54
Pg. 151996
(06 2022)
ISSN: 1532-866X [Electronic] United States |
PMID | 35339841
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
|
Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- Antirheumatic Agents
- Biological Products
- Interleukin-17
|
Topics |
- Antirheumatic Agents
(therapeutic use)
- Biological Products
(therapeutic use)
- Humans
- Interleukin-17
(therapeutic use)
- Quality of Life
- Randomized Controlled Trials as Topic
- Spondylitis, Ankylosing
(drug therapy)
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