Abstract | BACKGROUND: AIMS AND METHODS: A comprehensive literature search was conducted on the PubMed database up to December 2021 on the differential effect of animal versus vegetable protein on DKD. Articles written in English concerning human subjects were included. RESULTS: Animal protein is strongly associated with clinical features of DKD (glomerular hyperfiltration, albuminuria and kidney function decline) and CVD. Conversely, plant-sourced protein has a strong beneficial effect on both DKD and CVD. Plant-based diets have demonstrated to be nutritionally safe in subjects from the general population, patients with diabetes, and patients with kidney disease. Available evidence suggests that the dietary potassium load due to plant-sourced food does not usually induce hyperkalemia, although future research is required to establish the effect of meat (and subsequent insulin resistance) and vegetable food on kalemia. CONCLUSIONS: Nutritional advice to patients with diabetes should consider the strikingly different effect of animal versus vegetable protein on insulin resistance and its clinical consequences.
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Authors | María M Adeva-Andany, Carlos Fernández-Fernández, Natalia Carneiro-Freire, Matilde Vila-Altesor, Eva Ameneiros-Rodríguez |
Journal | Clinical nutrition ESPEN
(Clin Nutr ESPEN)
Vol. 48
Pg. 21-35
(04 2022)
ISSN: 2405-4577 [Electronic] England |
PMID | 35331493
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2022. Published by Elsevier Ltd. |
Chemical References |
- Dietary Proteins
- Plant Proteins, Dietary
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Topics |
- Animals
- Diabetes Mellitus
- Diabetic Nephropathies
(complications)
- Diet
- Dietary Proteins
- Humans
- Plant Proteins, Dietary
- Vegetables
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