Association Between Atopic Dermatitis, Asthma, and Serum Lipids: A UK Biobank Based Observational Study and Mendelian Randomization Analysis.

Abstract

Background:

Both atopic diseases and dysregulation of serum lipids (SLs) add to significant health burden, but evidences about their association are inconsistent.

Objective:

This work is to evaluate the association between asthma/atopic dermatitis (AD) and SLs and investigate the potential causal relationship.

Methods:

A large-scale cross-sectional study based on the UK Biobank (UKB) and then examined the casual relationships between SLs with asthma/AD based on a Mendelian randomization (MR) analysis.

Results:

A total of 502,505 participants were included in analysis. After full adjustment, AD was associated with lower TG (β = -0.006; 95%CI, -0.010 to -0.002; P = 0.006), lower LDL (β = -0.004; 95%CI, -0.006 to -0.002, P < 0.001), and lower TC (β = -0.004; 95%CI, -0.005 to -0.002; P < 0.001) but insignificantly correlated to HDL (P = 0.794). Asthma was also inversely correlated to TG (β = -0.005; 95%CI, = -0.007 to -0.003; < 0.001), LDL (β = -0.003; 95%CI, -0.004 to -0.002; P < 0.001), and TC (β = -0.002; 95%CI, -0.003 to -0.002; P < 0.001), but was positively correlated to HDL (β = 0.004; 95%CI, 0.003 to 0.005; P < 0.001), respectively. In subsequent MR analysis, both allergic diseases and asthma showed a protective effect on TC. Allergic diseases, asthma, and AD all showed a negative effect on LDL.

Conclusion:

Collectively, we identify a protective causal effect of allergic diseases on serum lipids, as well as a potentially positive association of HDL with asthma. Owing to the largest sample size and the application of IVs in causal inference, this study will provide a robust evidence for the management of asthma and AD and the prevention of dyslipidemia.

• Authors: Zhenwei Tang, Minxue Shen, Yi Xiao, Hong Liu, Xiang Chen
• Journal: Frontiers in medicine (Front Med (Lausanne)) Vol. 9 Pg. 810092 ( 2022) ISSN: 2296-858X [Print] Switzerland
• PMID: 35265637 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Tang, Shen, Xiao, Liu and Chen.