Current surgical single modality treatments for
hepatocellular carcinoma (HCC) were restricted by recurrence, blood loss, significant
trauma, and poor prognostic. Although multidisciplinary strategies for HCC treatment have been highly recommended by the clinical guidelines, there was limited choice of materials and treatments. Herein, we reported an in situ formed magnetic
hydrogel with promising bioapplicable thermal-responsiveness, strong adhesion in wet conditions, high magnetic
hyperthermia, and biocompatibility, leading to efficient HCC multidisciplinary treatment including postoperative treatment and transarterial embolization
therapy. In vivo results indicated that this
hydrogel could reduce the postoperative recurrence rate. The
hemostatic ability of the thermal-responsive
hydrogel was further demonstrated in both the liver scratch model and liver
tumor resection. Computed tomography imaging suggested that the
hydrogel could completely embolize the arterial vessels of rabbit liver
tumor by vascular intervention operation, which could serve as multidisciplinary responsive materials to external magnetic field and body temperature for HCC treatment.