Abstract | PURPOSE: OBSERVATIONS: A 57-year-old Chinese man complained of acute visual fields constriction in both eyes for 20 days. He was diagnosed with hepatocellular carcinoma 5 months earlier and treated with chemotherapy for 4 months. He was administered 100 mg of nivolumab as an immune checkpoint inhibitor treatment once every 2 weeks. After 2 cycles of nivolumab, he presented with acute visual problems and was referred to a neuro-ophthalmologist. Brain magnetic resonance imaging excluded optic nerve infiltration and brain metastasis. Optical coherence tomography revealed binocular diffuse loss of outer retinal structures like the circumferential fovea of the macula, and full-field electroretinography showed an almost extinguished response. A serum anti-paraneoplastic antibody panel was positive for anti- recoverin antibodies. He was diagnosed with cancer-associated retinopathy. He was treated with systemic steroids, followed by tryptophan immunoadsorption for 3 cycles. His visual field had slightly improved at a 2-year follow-up. CONCLUSIONS AND IMPORTANCE:
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Authors | Qian Chen, Chaoyi Feng, Chuanbin Sun, Wenji Wang, Min Wang, Ling Chen, Xinghuai Sun, Guohong Tian |
Journal | American journal of ophthalmology case reports
(Am J Ophthalmol Case Rep)
Vol. 25
Pg. 101370
(Mar 2022)
ISSN: 2451-9936 [Electronic] United States |
PMID | 35243142
(Publication Type: Case Reports)
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Copyright | © 2022 The Authors. |