High Remnant Cholesterol Level Potentiates the Development of Hypertension.
Abstract | Background: Emerging evidence suggests an association between remnant cholesterol (RC) and vascular damage and hypertension. However, this association has not been explored in a large-scale population in China, and a temporal relationship between RC and hypertension also needs to be investigated. Methods: We conducted a retrospective cross-sectional study in 2,199,366 individuals and a longitudinal study in 24,252 individuals with repeated measurements of lipid profile and blood pressure in at least a 3-year follow-up. The logistic model was used to explore the association between lipid components and hypertension in the cross-sectional analysis. The Cox model was used to analyze the association between high RC (HRC) at baseline and the subsequent incidence of hypertension or the association between hypertension at baseline and incidence of HRC. The cross-lagged panel model was applied to analyze the temporal relationship between RC and hypertension. Results: Conclusions: RC had an unexpected high correlation with the prevalence and incidence of hypertension. Moreover, RC increase might precede the development of hypertension, suggesting the potential role of RC in the development of hypertension.
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Authors | Ming-Ming Chen, Xuewei Huang, Chengsheng Xu, Xiao-Hui Song, Ye-Mao Liu, Dongai Yao, Huiming Lu, Gang Wang, Gui-Lan Zhang, Ze Chen, Tao Sun, Chengzhang Yang, Fang Lei, Juan-Juan Qin, Yan-Xiao Ji, Peng Zhang, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Feng Wan, Zhi-Gang She, Hongliang Li |
Journal | Frontiers in endocrinology
(Front Endocrinol (Lausanne))
Vol. 13
Pg. 830347
( 2022)
ISSN: 1664-2392 [Print] Switzerland |
PMID | 35222285
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Chen, Huang, Xu, Song, Liu, Yao, Lu, Wang, Zhang, Chen, Sun, Yang, Lei, Qin, Ji, Zhang, Zhang, Zhu, Cai, Wan, She and Li. |
Chemical References |
- Lipoproteins
- Triglycerides
- remnant-like particle cholesterol
- Cholesterol
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Topics |
- Adult
- Blood Pressure
- Cholesterol
(blood)
- Cross-Sectional Studies
- Female
- Humans
- Hypertension
(blood, epidemiology, etiology)
- Lipoproteins
(blood)
- Longitudinal Studies
- Male
- Middle Aged
- Retrospective Studies
- Triglycerides
(blood)
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